A novel pathogenic variant in the fibrinogen gamma chain gene p.Glu275Lys causes congenital hypofibrinogenemia

Blood Coagul Fibrinolysis. 2025 Apr 28. doi: 10.1097/MBC.0000000000001362. Online ahead of print.ABSTRACTCongenital hypofibrinogenemia presents not only with bleeding, but also paradoxically with thrombosis. This heterogeneity of clinical phenotype complicates both diagnosis and management. The thro

M Miroslava Drotarova

Hemolysis detection accuracy on Stago sthemO 301

No abstractBlood Coagul Fibrinolysis. 2025 Jun 1;36(4):134-135. doi: 10.1097/MBC.0000000000001359. Epub 2025 May 1.NO ABSTRACTPMID:40309991 | DOI:10.1097/MBC.0000000000001359

S Simone Denitto

An update on laboratory detection and interpretation of antiphospholipid antibodies for diagnosis of antiphospholipid syndrome: guidance from the ISTH-SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies: reply

No abstractJ Thromb Haemost. 2025 May;23(5):1732-1734. doi: 10.1016/j.jtha.2025.02.018.NO ABSTRACTPMID:40306820 | DOI:10.1016/j.jtha.2025.02.018

K Katrien M J Devreese

"An update on laboratory detection and interpretation of antiphospholipid antibodies for diagnosis of antiphospholipid syndrome: Guidance from the International Society on Thrombosis and Haemostasis Scientific and Standardization Committee (ISTH-SSC) Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies": comment

No abstractJ Thromb Haemost. 2025 May;23(5):1730-1731. doi: 10.1016/j.jtha.2025.01.018.NO ABSTRACTPMID:40306819 | DOI:10.1016/j.jtha.2025.01.018

K Karl J Lackner

Antithrombotic effect and plasma pharmacochemistry of Justicia Procumbens L

PLoS One. 2025 Apr 30;20(4):e0321023. doi: 10.1371/journal.pone.0321023. eCollection 2025.ABSTRACTIMPORTANCE: Justicia procumbens L. contains lignans with remarkable antiplatelet aggregation effects. Its ethyl acetate extract has demonstrated the efficacy of inhibiting platelet aggregation in prelim

H Hui Zhang

A Map of the Lipid-Metabolite-Protein Network to Aid Multi-Omics Integration

Biomolecules. 2025 Mar 26;15(4):484. doi: 10.3390/biom15040484.ABSTRACTThe integration of multi-omics data offers transformative potential for elucidating complex molecular mechanisms underlying biological processes and diseases. In this study, we developed a lipid-metabolite-protein network that co

U Uchenna Alex Anyaegbunam

Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of αIIbβ3 and Modulation of Fibrinogen

Biomolecules. 2025 Mar 29;15(4):501. doi: 10.3390/biom15040501.ABSTRACTIn the vascular system, pathological conditions that cause hypoxia are associated with increased platelet activity and thrombosis. Using a platelet spreading assay, we show that severe hypoxia (i.e., 1%), venous (i.e., 5%), and,

S Sophie V L Leonard

SARS-COV-2 causes significant abnormalities in the fibrinolysis system of patients: correlation between viral mutations, variants and thrombosis

Front Cell Infect Microbiol. 2025 Apr 15;15:1531412. doi: 10.3389/fcimb.2025.1531412. eCollection 2025.ABSTRACTBACKGROUND: Coronavirus disease (COVID-19) is reported as a complex disorder affecting multiple systems and coagulopathy that can cause mortality. In this study, we investigated the correla

E Esra'a Abudouleh

Cisplatin reduces immunosuppression caused by tumor-associated macrophages through downregulating CD47-SIRPα signaling in glioblastoma

Biochim Biophys Acta Mol Basis Dis. 2025 Apr 27:167876. doi: 10.1016/j.bbadis.2025.167876. Online ahead of print.ABSTRACTThe poor prognosis of glioblastoma (GBM) is partly attributed to the immunosuppressive microenvironment. The combination of standard temozolomide and other chemotherapy drugs can

Y Yanyan Li

Generation of a Severe Hemophilia A Humanized Mouse Model Capable of Inducing an Anti-FVIII Immune Response

Thromb Haemost. 2025 May;125(5):435-446. doi: 10.1055/a-2518-7157. Epub 2025 Apr 29.ABSTRACTFactor VIII (FVIII) replacement therapy induces anti-FVIII neutralizing antibodies in approximately 30% of patients with severe hemophilia A (HA). Owing to the lack of experimental systems that allow for the

A Akihisa Oda

Clinical and laboratorial characterization of a cohort of patients with hereditary platelet disorders in Brazil

Hematol Transfus Cell Ther. 2025 Apr 28;47(2):103837. doi: 10.1016/j.htct.2025.103837. Online ahead of print.ABSTRACTINTRODUCTION: Inherited platelet disorders are rare conditions characterized by altered platelet function and/or reduced platelet counts. Diagnosing these disorders is challenging and

L Letícia Dalla Vecchia Grassi

Disulfide bond control of platelet αIIbβ3 integrin

Thromb Res. 2025 Apr 16;250:109320. doi: 10.1016/j.thromres.2025.109320. Online ahead of print.ABSTRACTThe platelet αIIbβ3 integrin is the most abundant platelet receptor, orchestrating platelet adhesion, activation, and mechano-sensing during hemostasis and thrombosis. Disulfide bonds are the coval

A Aster E Pijning

Advanced Research in the Pathophysiology of Venous Thromboembolism-Acute Pulmonary Embolism

Biomedicines. 2025 Apr 8;13(4):906. doi: 10.3390/biomedicines13040906.ABSTRACTAccording to the literature, cardiovascular diseases (CVDs)-including myocardial infarction, stroke, and venous thromboembolism (VTE)-are among the leading causes of mortality and morbidity worldwide. Evidence suggests tha

A Anna M Imiela

Parenteral anticoagulants. Update on use and monitoring of heparin and its derivatives

Medicina (B Aires). 2025 Apr;85 Suppl 2:1-45.ABSTRACTHeparin and its different formulations and derivatives, the first and second generation low molecular weight heparins and pentasaccharides, are indirect parenteral anticoagulants that, with limitations and difficulties, continue to have a privileg

J José M Ceresetto

Fibrinogen Oxidation and Thrombosis: Shaping Structure and Function

Antioxidants (Basel). 2025 Mar 26;14(4):390. doi: 10.3390/antiox14040390.ABSTRACTFibrinogen, a pivotal plasma glycoprotein, plays an essential role in hemostasis by serving as the precursor to fibrin, which forms the structural framework of blood clots. Beyond coagulation, fibrinogen influences immu

F Francesca Nencini

European Principles of Nursing Care for Persons With Inherited Bleeding Disorders

Haemophilia. 2025 Apr 29. doi: 10.1111/hae.70054. Online ahead of print.ABSTRACTINTRODUCTION: A nurse is one of the core members of the multidisciplinary haemophilia team. However, what people with inherited bleeding disorders (PwBD) can expect from them has not yet been formally defined.AIM: This p

N Nanda Uitslager

Bridging Therapy and Risk of Bleeding and Thrombosis in Continuous-Flow Left Ventricular Assist Device Patients: A Quasi-Experimental Study

ASAIO J. 2025 Apr 29. doi: 10.1097/MAT.0000000000002447. Online ahead of print.ABSTRACTBridging with low-molecular-weight heparin (LMWH) is recommended in continuous-flow left ventricular assist device (CF-LVAD) patients during subtherapeutic international normalized ratios (INRs). We aimed to asses

E Eleonora Camilleri

Anti-PF4 mediated thrombocytopenia and thrombosis associated with acute cytomegalovirus infection displays both HIT-like and VITT-like characteristics

Br J Haematol. 2025 Apr 29. doi: 10.1111/bjh.20092. Online ahead of print.ABSTRACTVaccine-induced immune thrombocytopenia and thrombosis (VITT) is one of several anti-platelet factor 4 (anti-PF4)-associated immune thrombocytopenia and thrombosis (PITT) syndromes. As well as following adenoviral vect

P Phillip L R Nicolson

Predictive value of combined examination of coagulation and fibrinolysis indexes for deep venous thrombosis after proximal femoral nail anti-rotation in elderly patients with femoral intertrochanteric fracture

Zhongguo Gu Shang. 2025 Apr 25;38(4):371-7. doi: 10.12200/j.issn.1003-0034.20231098.ABSTRACTOBJECTIVE: To investigate the prognostic significance of combined coagulation and fibrinolysis marker analysis in predicting the development of deep venous thrombosis (DVT) following proximal femoral anti-rot

H Hong-Feng Zhang

Evaluation of a 4 min 4000g centrifugation protocol for routine coagulation assays

Blood Coagul Fibrinolysis. 2025 Apr 24. doi: 10.1097/MBC.0000000000001363. Online ahead of print.ABSTRACTCentrifugation is a critical step in sample preparation and accounts for an important part of turnaround time. This step is further critical for hemostasis, which requires a low platelet count to

S Sylvain Lamoine

Management of Short Saphenous Vein Thrombosis Close to the Saphenopopliteal Junction: A Survey of the Membership of HaemSTAR, British Society for Haemostasis and Thrombosis and VTE Exemplar Centres in the United Kingdom

EJHaem. 2025 Apr 26;6(3):e70037. doi: 10.1002/jha2.70037. eCollection 2025 Jun.ABSTRACTINTRODUCTION: The optimal management of superficial thrombophlebitis (STP) close to the saphenopopliteal junction (SPJ) is not known.METHODS: We conducted an online survey of members of the HaemSTAR network, Briti

K Kirollos Salah Kamel

An assessment of evidence to inform best practice for the communication of acute venous thromboembolism diagnosis: a scoping review

Res Pract Thromb Haemost. 2025 Mar 23;9(3):102835. doi: 10.1016/j.rpth.2025.102835. eCollection 2025 Mar.ABSTRACTBACKGROUND: Physician communication with patients is a key aspect of excellent care. Scant evidence exists to inform best practice for physician communication in patients diagnosed with p

S Samarth Mishra

Metabolomic liquid biopsy dynamics predict early-stage HCC and actionable candidates of human hepatocarcinogenesis

JHEP Rep. 2025 Jan 30;7(5):101340. doi: 10.1016/j.jhepr.2025.101340. eCollection 2025 May.ABSTRACTBACKGROUND & AIMS: Actionable candidates of hepatocarcinogenesis remain elusive, and tools for early detection are suboptimal. Our aim was to demonstrate that serum metabolome profiles reflect the initi

K Kornelius Schulze

Persisting thrombomodulin resistance at 3 months after liver transplantation in children with cirrhosis

Res Pract Thromb Haemost. 2025 Feb 27;9(2):102709. doi: 10.1016/j.rpth.2025.102709. eCollection 2025 Feb.ABSTRACTBACKGROUND: The coagulation cascade in pediatric cirrhotic patients appears rebalanced, similar to adults, with few true hemostasis-related bleeds or thromboembolic events before liver tr

M Marie-Astrid van Dievoet