Sci Rep. 2025 May 1;15(1):15309. doi: 10.1038/s41598-025-98991-0.ABSTRACTInflammatory bowel disease (IBD) is an autoimmune disease (AD) characterized by chronic, relapsing intestinal inflammation. Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystem involvement and ove
Autoimmun Rev. 2025 Apr 29:103825. doi: 10.1016/j.autrev.2025.103825. Online ahead of print.ABSTRACTMultiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system (CNS), characterized by demyelination, neuroinflammation, and the progressive accumulation of neurologic deficits
Thromb Haemost. 2025 May 1. doi: 10.1055/a-2523-1821. Online ahead of print.ABSTRACTInflammation and thrombosis are traditionally considered two separate entities of acute host responses to barrier breaks. While inciting inflammatory responses is a prerequisite to fighting invading pathogens and sub
Nat Commun. 2025 May 1;16(1):4082. doi: 10.1038/s41467-025-59147-w.ABSTRACTCD200R is a checkpoint inhibitory receptor central to the pathogenesis of inflammatory skin disease. Here we describe the development and phase 1 clinical study (NCT03750643) of ucenprubart, a CD200R agonist antibody to downr
Invest Ophthalmol Vis Sci. 2025 May 1;66(5):3. doi: 10.1167/iovs.66.5.3.ABSTRACTPURPOSE: Nicotinamide N-methyltransferase (NNMT) has been implicated in inflammatory autoimmune disease pathogenesis, although its pro-inflammatory role in Graves' orbitopathy (GO) is unclear. Therefore, we investigated
No abstractCASE (Phila). 2025 Feb 22;9(4):114-118. doi: 10.1016/j.case.2024.12.010. eCollection 2025 Apr.ABSTRACTPMID:40309466 | PMC:PMC12038187 | DOI:10.1016/j.case.2024.12.010
Front Immunol. 2025 Apr 16;16:1569632. doi: 10.3389/fimmu.2025.1569632. eCollection 2025.ABSTRACTHigh-mobility group box 1 (HMGB1) is expressed in almost all human cells. During cell activation and cell death, the nucleoprotein HMGB1 can translocate to the extracellular space, thus mediating the ear
Front Immunol. 2025 Apr 16;16:1566985. doi: 10.3389/fimmu.2025.1566985. eCollection 2025.ABSTRACTKawasaki disease (KD) is a relatively common autoimmune disease of childhood, characterized by systemic vasculitis and involvement of the cardiovascular system, particularly the coronary artery. Progress
Front Immunol. 2025 Apr 16;16:1551911. doi: 10.3389/fimmu.2025.1551911. eCollection 2025.ABSTRACTSystemic Sclerosis (SSc) is a systemic autoimmune disease of unknown etiology characterized by the development of frequently progressive cutaneous and internal organ fibrosis accompanied by severe vascul
J Clin Neurol. 2025 May;21(3):213-219. doi: 10.3988/jcn.2024.0469.ABSTRACTBACKGROUND AND PURPOSE: Guillain-Barré syndrome (GBS) is an autoimmune-mediated disorder characterized by demyelinating or axonal injury of the peripheral nerve. Our aim is to determine whether serum amyloid A (SAA) is a bioma
J Neuroinflammation. 2025 Apr 30;22(1):127. doi: 10.1186/s12974-025-03450-2.ABSTRACTBACKGROUND AND OBJECTIVES: Ataxin-1 (ATXN1) is a protein in which expansion of its polyglutamine tract causes the neurodegenerative disorder spinocerebellar ataxia type 1 (SCA1) via a gain-of-function. Wild type ATXN
During the twentieth century, inflammatory bowel disease (IBD) was considered a disease of early industrialized regions in North America, Europe and Oceania¹. At the turn of the twenty-first century, IBD incidence increased in newly industrialized and emerging regions in Africa, Asia and Latin Ameri
Clin Rheumatol. 2025 Apr 30. doi: 10.1007/s10067-025-07403-1. Online ahead of print.ABSTRACTBACKGROUND: Rheumatic disease is a kind of disease dominated by inflammatory lesions of connective tissue and abnormal immune function. It mostly belongs to autoimmune diseases or connective tissue diseases a
Much remains unknown regarding T follicular helper 17 (T(FH)17) cells commonly found in autoimmune patients. We previously showed that (and here ask why) egress of gut segmented filamentous bacteria (SFB)-induced T(FH) cells from Peyer's patches (PP) to systemic sites promotes arthritis. We found sp
Nihon Yakurigaku Zasshi. 2025;160(3):172-176. doi: 10.1254/fpj.25005.ABSTRACTChemokines are a group of cytokines which are involved in the migration of immune cells as well as other cell types such as endothelial cells. These molecules normally regulate the homeostasis in our body's immune system. F
Cell Immunol. 2025 Apr 12;411-412:104952. doi: 10.1016/j.cellimm.2025.104952. Online ahead of print.ABSTRACTBACKGROUND: Adoptive transfer of regulatory T cells (Tregs) has been proposed as a next-generation treatment approach for the treatment of various inflammatory or autoimmune disorders(Amini et
Int Immunopharmacol. 2025 Apr 29;157:114693. doi: 10.1016/j.intimp.2025.114693. Online ahead of print.ABSTRACTMyeloid-derived suppressor cells (MDSCs) encompass monocytes and granulocytes, which are innate immune cells capable of suppressing T cells and NK cells. MDSCs exert numerous detrimental eff
Acta Pharm. 2025 Apr 30. doi: 10.2478/acph-2025-0011. Online ahead of print.ABSTRACTToll-like receptors (TLRs) are essential for the innate immune system as they recognize pathogen-associated molecular patterns and trigger immune responses. Overactivation of TLR8 by endogenous nucleic acids is assoc
Biomolecules. 2025 Apr 16;15(4):590. doi: 10.3390/biom15040590.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by the inflammation of synovial fluid. The incidence of cardiovascular diseases (CVDs) is increasing in RA patients. This research is the first
Biomolecules. 2025 Mar 31;15(4):505. doi: 10.3390/biom15040505.ABSTRACTNeutrophils are increasingly recognized as key contributors to the pathogenesis of Type 1 Diabetes (T1D), yet their precise mechanistic role in disease onset and progression remains incompletely understood. While these innate imm
Biomolecules. 2025 Mar 25;15(4):480. doi: 10.3390/biom15040480.ABSTRACTFriend leukemia virus integration 1 (Fli-1), a member of the ETS family of transcription factors, plays an essential role in diverse biological processes. Recent studies have underscored the significance of Fli-1 in modulating in
J Am Anim Hosp Assoc. 2025 May 1;61(3):68-73. doi: 10.5326/JAAHA-MS-7456.ABSTRACTA 3 yr old intact male Doberman pinscher was referred with chronic diarrhea, severe polyuria-polydipsia, and behavioral changes for 2 wk. Biochemical abnormalities were consistent with central diabetes insipidus, hypoth
Pediatr Transplant. 2025 Jun;29(4):e70082. doi: 10.1111/petr.70082.ABSTRACTBACKGROUND: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that can progress to liver cirrhosis and end-stage liver disease, often necessitating liver transplantation (LT). Pediatric LT has significantly i
Front Pharmacol. 2025 Apr 15;16:1546836. doi: 10.3389/fphar.2025.1546836. eCollection 2025.ABSTRACTVitiligo is a chronic autoimmune condition characterized by the destruction of melanocytes, leading to patchy loss of skin depigmentation. Although its precise cause remains unclear, recent evidence su
