Biomolecules. 2025 Mar 25;15(4):480. doi: 10.3390/biom15040480.
ABSTRACT
Friend leukemia virus integration 1 (Fli-1), a member of the ETS family of transcription factors, plays an essential role in diverse biological processes. Recent studies have underscored the significance of Fli-1 in modulating inflammation and autoimmune diseases via the regulation of inflammatory responses. Specifically, Fli-1 exerts control over inflammatory processes, influencing key effectors and signaling pathways associated with conditions such as systemic lupus erythematosus, scleroderma, cancer, and sepsis. This review aims to summarize the emerging roles of Fli-1 in inflammation and autoimmune diseases, with a focus on elucidating the underlying molecular mechanisms and exploring the potential therapeutic implications.
PMID:40305194 | PMC:PMC12024840 | DOI:10.3390/biom15040480