JBJS Case Connect. 2025 May 1;15(2). doi: 10.2106/JBJS.CC.25.00059. eCollection 2025 Apr 1.
ABSTRACT
CASE: An 88-year-old woman presented with worsening right hip pain over 2 years. Radiographs were unremarkable, but magnetic resonance imaging identified a femoral neck lesion. A computed tomography-guided biopsy revealed a zellballen pattern of cells positive for chromogranin and synaptophysin. Further workup, including a metaiodobenzylguanidine scan confirmed focal uptake at the right femoral neck. After multidisciplinary discussion, and shared decision-making with the patient, conservative management was chosen.
CONCLUSION: Primary intraosseous paragangliomas are rare, with this case representing only the second reported in femur and third in the appendicular skeleton. It underscores the importance of a multimodal diagnostic approach, individualized treatment plans, and multidisciplinary collaboration.
PMID:40311000 | DOI:10.2106/JBJS.CC.25.00059