J Geriatr Psychiatry Neurol. 2025 May 1:8919887251339837. doi: 10.1177/08919887251339837. Online ahead of print.ABSTRACTBackgroundSubjective memory complaints (SMC) are common in older adults and may indicate an increased risk of cognitive decline. Polypharmacy and anticholinergic burden have been a
BMJ Open. 2025 Apr 29;15(4):e094545. doi: 10.1136/bmjopen-2024-094545.ABSTRACTOBJECTIVE: Potentially inappropriate prescribing is a global health issue with catastrophic consequences in the elderly population. Healthcare providers play a critical role in medication optimisation in elderly patients.
BMC Pharmacol Toxicol. 2025 Apr 29;26(1):92. doi: 10.1186/s40360-025-00926-y.ABSTRACTBACKGROUND: Elderly patients are at a heightened risk of drug-drug interactions due to their high prevalence of comorbidities, polypharmacy, and age-related physiological changes that alter drug metabolism and excre
BMC Infect Dis. 2025 Apr 29;25(1):629. doi: 10.1186/s12879-025-11044-9.ABSTRACTBACKGROUND: Infectious disease continues to be a major cause of death among pediatrics. Drug therapy problem (DTP) is a significant public health challenge that is highly prevalent in pediatrics, and it has an impact on t
Drugs Aging. 2025 Apr 29. doi: 10.1007/s40266-025-01194-5. Online ahead of print.ABSTRACTINTRODUCTION: Polypharmacy is common in older patients and associated with adverse outcomes. However, the association with outcomes in patients with intertrochanteric fractures remains unclear. This study aimed
J Multimorb Comorb. 2025 Apr 24;15:26335565251336425. doi: 10.1177/26335565251336425. eCollection 2025 Jan-Dec.ABSTRACTBACKGROUND: The dynamics of working within multidisciplinary teams (MDTs) to manage diabetes and comorbidities remain underexplored. Investigating physicians' experiences provide in
Eur J Clin Pharmacol. 2025 Apr 28. doi: 10.1007/s00228-025-03845-3. Online ahead of print.ABSTRACTPURPOSE: This review evaluated publications that described medicine risk assessment tools developed or adapted for use in Australia to assess risks associated with medicine-related problems (MRPs). It e
Fam Med Community Health. 2025 Apr 28;13(2):e003250. doi: 10.1136/fmch-2024-003250.ABSTRACTBACKGROUND: Clinical guidelines recommend frailty screening for the aged population, given that frailty is frequently reversible. However, little is known about frailty and prefrailty reversal rates in the gen
J Clin Med. 2025 Apr 13;14(8):2665. doi: 10.3390/jcm14082665.ABSTRACTBackground/Objectives: Trauma is a psychological injury resulting from a distressing or overwhelming event. The SARS-CoV-2 pandemic has been disruptive and traumatic for many people with multiple sclerosis (pwMS). The relationship
Medicina (Kaunas). 2025 Mar 28;61(4):614. doi: 10.3390/medicina61040614.ABSTRACTBackground and Objectives: HCV infection represents a main risk factor for type 2 diabetes (T2D). This real-world analysis investigated the HCV-positive (HCV+) population with a T2D co-diagnosis in Italy. Methods: From 2
Sci Rep. 2025 Apr 25;15(1):14486. doi: 10.1038/s41598-025-99566-9.ABSTRACTThe aim of this study is to determine the influence of ARV on the diagnosis of frailty in PLWH. A single-centre prospective observational study was conducted involving PLWH over 18 years old who attended a hospital pharmacy ou
J Med Case Rep. 2025 Apr 23;19(1):188. doi: 10.1186/s13256-025-05209-y.ABSTRACTBACKGROUND: Venlafaxine, a serotonin-norepinephrine reuptake inhibitor, is commonly prescribed for depressive and anxiety disorders, with a safety profile comparable to selective serotonin reuptake inhibitors. Although ve
BMC Infect Dis. 2025 Apr 23;25(1):587. doi: 10.1186/s12879-025-10988-2.ABSTRACTINTRODUCTION/OBJECTIVE: This Turkish study aimed to investigate the factors that contribute to the failure of virological suppression in people with human immunodeficiency virus (HIV) receiving antiretroviral therapy (ART
Acta Med Indones. 2025 Jan;57(1):74-80.ABSTRACTBACKGROUND: Geriatric patients are often subject to polypharmacy, increasing their risk of adverse drug reactions (ADRs). This study evaluated polypharmacy practices, ADR incidence, predictive factors, and the applicability of the GerontoNet Score at a
Mult Scler Relat Disord. 2025 Mar 31;98:106415. doi: 10.1016/j.msard.2025.106415. Online ahead of print.ABSTRACTBACKGROUND: Approximately half of people with Multiple Sclerosis (pwMS) have cognitive difficulties, including problems with executive functioning, attention, learning, memory and informat
Front Pharmacol. 2025 Apr 7;16:1455753. doi: 10.3389/fphar.2025.1455753. eCollection 2025.ABSTRACTBACKGROUND: Salivary microbiome alterations are associated with chronic diseases, such as cardiovascular disease, diabetes, and dementia. These chronic diseases often coexist in older adults, leading to
Eur J Heart Fail. 2025 Apr 20. doi: 10.1002/ejhf.3652. Online ahead of print.ABSTRACTAIMS: The necessity of lifelong treatment and polypharmacy in chronic heart failure (HF) patients with improved myocardial function remains debated. This systematic review aims to synthesize current literature regar
Neurol Res Pract. 2025 Apr 21;7(1):25. doi: 10.1186/s42466-025-00379-y.ABSTRACTBACKGROUND: The decision to discontinue disease-modifying therapies (DMTs) in patients with multiple sclerosis (PwMS) is a critical clinical challenge. Historically, DMTs were discontinued due to side effects, treatment l
Curr Drug Metab. 2025 Apr 17. doi: 10.2174/0113892002358291250401190533. Online ahead of print.ABSTRACTBACKGROUND: When managing diabetes, polypharmacy the use of several drugs simultaneously to obtain the best possible glucose control is typical. Drug-drug interactions (DDIs), which can result in s
Rev Esp Quimioter. 2025 Apr 16;38(4):032.2025. doi: 10.37201/req/032.2025.ABSTRACTINTRODUCTION: Advances in antiretroviral therapy (ARV) have improved the life expectancy of people living with HIV (PLWH), shifting the focus to quality of life (QoL). However, aging, polypharmacy, and comorbidities po
Aging Clin Exp Res. 2025 Apr 12;37(1):123. doi: 10.1007/s40520-025-02973-1.ABSTRACTOsteoporosis is a critical public health issue, particularly in the "older" (those aged over 75) and "oldest old" population (those aged 85 and above), who are at a heightened risk for fractures and related complicati
J Clin Med. 2025 Mar 28;14(7):2328. doi: 10.3390/jcm14072328.ABSTRACTAtrial fibrillation (AF) is the most prevalent sustained supraventricular arrhythmia, particularly in older adults, with its incidence increasing dramatically with age. This condition is a significant contributor to morbidity and m
BMJ Open. 2025 Apr 10;15(4):e091997. doi: 10.1136/bmjopen-2024-091997.ABSTRACTOBJECTIVES: Factors associated with multimorbidity, polypharmacy and Medication Regimen Complexity Index (MRCI) may vary across countries. However, such data are lacking in the present study setting. This study aimed to id
J Eval Clin Pract. 2025 Apr;31(3):e70088. doi: 10.1111/jep.70088.ABSTRACTRATIONALE: In healthcare systems without gatekeeper access to Emergency Departments (ED), the number of people presenting for low back pain (LBP) is increasing substantially. Low back pain presentations at the Emergency Departm
